Status:
UNKNOWN
BMI Effect on the Response to Ovulation Induction in Letrozole vs Clomid
Lead Sponsor:
Cairo University
Conditions:
Subfertility
Eligibility:
FEMALE
18-45 years
Phase:
PHASE4
Brief Summary
There is an increased prevalence of high Body mass index (BMI) all over the world.High BMI is shown to have an impact on the female reproductive system.It can contribute to both ovulatory and anovulat...
Detailed Description
This is a Randomized controlled trial .The researchers include160 women with BMI more than 30 who were suffering from subfertility for more than 2 years. The investigators will randomise them into 2 g...
Eligibility Criteria
Inclusion
- Age: 18-45 years old.
- History of subfertility for 2 years.
- No previous IVF
- Intact tubes as evidenced by HSG or Hycosy
- Normal Sperm parameters according to WHO criteria.
- Ability to have regular intercourse during the ovulation induction phase of the study.
Exclusion
- Age less than 18 years old or older than 45 years old.
- FSH\> 15 mIU/ml
- Tubal factor of infertility
- Male factor of infertility
- Current pregnancy,abnormal uterine bleeding.
- History of use of hormonal contraception in the last 3 months.
- Untreated medical problems: thyroid disease,hyperprolactinemia or contraindication to pregnancy as uncontrolled diabetes or severe heart disease.
- Contraindications to clomiphene citrate: hypersensitivity to clomid.
- Contraindications to letrozole: hypersensitivity to letrozole .
Key Trial Info
Start Date :
May 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04331197
Start Date
May 1 2020
End Date
June 1 2021
Last Update
April 2 2020
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