Status:
ACTIVE_NOT_RECRUITING
The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
University of Cambridge
Lundbeck Foundation
Conditions:
Obsessive-Compulsive Disorder/High Compulsive Individuals
Healthy Individuals
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
The aim of this project is to investigate: * The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administ...
Detailed Description
Previous studies have shown that 5-HT is strongly implicated in compulsive behaviours in experimental animals. Manipulation of 5-HT influences neuronal interactions underlying action selection. Reduce...
Eligibility Criteria
Inclusion
- Individuals with high scores on obsessive-compulsive traits (with or without a diagnosis of OCD established by a psychiatrist) and healthy volunteers (male or female) between 18 and 70 years. Compulsive individuals without an OCD diagnosis are individuals without a history of psychiatric or other major medical conditions but scoring abnormally high on the Obsessive-Compulsive Inventory (OCI) questionnaire.
Exclusion
- Current or previous neurological disease, severe somatic disease, or consumption of medical drugs likely to influence the test results
- Non- fluent in Danish or pronounced visual or auditory impairments
- Current or past learning disability.
- Pregnancy
- Lactation
- Participation in experiments with radioactivity (\> 10 mSv) within the last year or significant occupational exposure to radioactivity.
- Contraindications for MRI (pacemaker, metal implants, etc.).
- Allergy to the ingredients in the administered drug.
- Abnormal ECG (e.g. prolonged QT syndrome).
- Dizzy when changing from supine to upright position (e.g. postural orthostatic tachycardia syndrome).
- Mild hypotension (blood pressure below 100/70 mmHg) or hypertension (blood pressure above 140/90 mmHg).
- Head injury or concussion resulting in loss of consciousness for more than 2 min.
- Alcohol or drug abuse
- Drug use other than tobacco and alcohol within the last 30 days.
- Hash \> 50 x lifetime.
- Drugs \> 10 x lifetime (for each substance).
- Current medication with serotonergic acting compounds. Use of other psychoactive substances must be stable at least one month prior to inclusion and maintained throughout the study.
- Severe physical impairments affecting eyesight or motor performance.
- For the OCD group: other Axis I mental disorder as primary diagnosis according to ICD-10 criteria.
- For healthy volunteers: any current or former primary psychiatric disorder (Axis I WHO ICD-10 diagnostic classification).
Key Trial Info
Start Date :
April 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2027
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04336228
Start Date
April 1 2020
End Date
December 31 2027
Last Update
December 18 2024
Active Locations (1)
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1
Neurobiology Research Unit, Rigshospitalet
Copenhagen, Denmark, 2100