Status:
COMPLETED
Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain
Lead Sponsor:
Medical University of South Carolina
Conditions:
Healthy Adults
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The anterior nuclei of the thalamus in addition to periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) are integral regions of a supraspinal opioidergic structure that regulate pain perce...
Detailed Description
LIFUP uses a single large concave, or multiple ultrasound transducers in a cap placed on the scalp to produce high frequency (100Hz) sonications for 30 seconds at a time for 10 trains of pulses. Unlik...
Eligibility Criteria
Inclusion
- 18-45 years of age
- Healthy volunteer
Exclusion
- seizure history (individual or family)
- history of depression
- hospitalizations or surgeries in the previous 6 months
- currently experiencing pain
- history of chronic pain
- metal implants or objects (e.g. pacemakers, metal plates, wires)
- pregnant
- alcohol dependence
- illicit drug use in the previous 6 months
- known allergy to capsaicin
- history of brain surgery or brain lesions
- history of loss of consciousness (greater than 15 min)
- on stimulants or medications that lower seizure threshold.
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2021
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT04339972
Start Date
February 1 2019
End Date
July 1 2021
Last Update
August 19 2021
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425