Status:
WITHDRAWN
Coronavirus Response - Active Support for Hospitalised Covid-19 Patients
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Conditions:
Covid-19
Eligibility:
All Genders
40+ years
Phase:
PHASE3
Brief Summary
The CRASH-19 trial is a multinational, open-label, factorial, randomised trial in adults hospitalised with suspected or confirmed acute COVID-19 infection.
Detailed Description
We will evaluate the effect of aspirin (150mg once daily), losartan (100mg once daily), and simvastatin (80mg once daily) in patients with COVID-19 infection. Eligible patients will be randomly alloc...
Eligibility Criteria
Inclusion
- Adults age 40 years and older
- with suspected or confirmed acute COVID-19 infection. Acute COVID-19 infection is suspected in the presence of a fever and at least one symptom of respiratory disease e.g. cough, difficulty breathing, signs of hypoxia. The clinician may suspect COVID-19 infection if i) the patient lives in or has recently travelled to an area with COVID-19 transmission; ii) the patient had recent contact with a confirmed or probable COVID-19 case, or iii) no alternative diagnosis fully explains the clinical presentation
- requiring hospitalisation
Exclusion
- Women known to be pregnant
- Patients hospitalised without symptoms of acute COVID-19 infection should not be recruited even if they test positive for COVID-19
- Patients already receiving mechanical ventilation
- Patients with a definite indication or contraindication for any of the trial treatments.
- Patients who are very severely frail (completely dependent and approaching end of life who typically they could not recover even from a mild illness) or terminally ill should not be recruited.
Key Trial Info
Start Date :
October 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04343001
Start Date
October 1 2020
End Date
August 1 2021
Last Update
November 19 2020
Active Locations (2)
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1
University College Hospital
Ibadan, Oyo State, Nigeria
2
Shifa Tameer-e-Millat University
Rawalpindi, Pakistan