Status:
COMPLETED
Respiratory and Hemodynamic Changes Induced in Mechanically Ventilated Patients for COVID-19
Lead Sponsor:
University Hospital, Lille
Conditions:
COVID-19
ARDS
Eligibility:
All Genders
18+ years
Brief Summary
In the present context, it seems necessary to try to describe as precisely as possible the physiological alterations due to COVID-19. From these observations, therapeutic proposals adapted to this new...
Eligibility Criteria
Inclusion
- hospitalized in intensive care for a SARS-CoV2 infection
- requiring invasive ventilation,
- intubated for less than 72 hours with PaO2/FiO2 ratio \< 200 mmHg
Exclusion
- Patient mechanically ventilated for 72 hours or more
- Patient with documented respiratory co-infection
- Patient with a contraindication to pulmonary artery catheter insertion: High risk of bleeding, pre-existing high degree of atrioventricular heart block , Pace Maker
- Patient with spontaneous ventilation
- Patient with severe ARDS with static compliance of the respiratory system \< 20 mL/cmH2O
- Patient with severe ARDS with indication of prone positioning at inclusion.
- Patient with a cardiac condition that renders the measurement of pulmonary artery occlusion pressure uninterpretable as a surrogate for left ventricle end diastolic pressure (severe mitral insufficiency, severe mitral stricture, severe aortic insufficiency).
- Patient with intracardiac shunt
- Patient with ECMO
- Minors and pregnant women.
- Person not affiliated to or not benefiting from a social security scheme.
Key Trial Info
Start Date :
April 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 6 2020
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04347928
Start Date
April 20 2020
End Date
November 6 2020
Last Update
November 17 2020
Active Locations (1)
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1
Hopital Roger Salengro, CHU Lille
Lille, France, 59037