Status:
COMPLETED
Management of Ovarian Hyperstimulation Syndrome as a State of Defective Mineralocorticoid Response
Lead Sponsor:
Ganin Fertility Center
Conditions:
Ovarian Hyperstimulation Syndrome
Eligibility:
FEMALE
18-40 years
Phase:
PHASE2
Brief Summary
lines of evidence that support nature of ovarian hyperstimulation syndrome (OHSS) as "defective mineralocorticoid response" are cited, our hypothesis is tested clinically in both prophylaxis against a...
Detailed Description
several studies state significant correlation between OHSS and activation of Renin-angiotensin-aldosterone system (RAAS), degree of activation of RAAS correlates with severity of OHSS. In OHSS there i...
Eligibility Criteria
Inclusion
- patients undergoing ICSI who were considered at risk of developing OHSS:
- polycystic ovaries and/or previous history of OHSS, AMH \> 40 pmol/L but patients were finally included in the study if serum E2 levels reached \>3000 pg/ml on day of hCG trigger or at any stage of folliculometry
- age: 18-40
Exclusion
- retrieval of less than 20 oocytes
- age less than 18 or above 40
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 29 2020
Estimated Enrollment :
107 Patients enrolled
Trial Details
Trial ID
NCT04351126
Start Date
April 1 2019
End Date
February 29 2020
Last Update
April 17 2020
Active Locations (1)
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1
Ganin Fertility Center
Cairo, Maadi, Egypt, 11728