Status:
COMPLETED
Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis
Lead Sponsor:
China Medical University Hospital
Collaborating Sponsors:
TOP Pharm & Medicalware
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
This study was a randomized, double-blind, placebo-controlled study evaluating the efficacy of an oral liquid HA supplement (A+HA) in symptoms relief and improvement of quality of life in knee osteoar...
Detailed Description
Subjects were initially screened at the Randomization/Baseline Visit (Week 0). Eligible subjects were randomized at the same visit into the treatment period and received the assigned treatment in a do...
Eligibility Criteria
Inclusion
- Male or female age \>= 40 years old
- Diagnosed with knee OA which met the definition of Ahlbӓck classification12 and had knee joint symptoms within 30 days prior to enrollment
Exclusion
- Had administered glucosamine one month prior to enrollment
- Had known allergy to oral HA
- BMI ≧40 kg/m2
- Knee OA was caused by occupational hazard or sports injury
- Patients with known other causes of arthritis (infectious rheumatoid or psoriatic arthritis), bony or soft tissue malignancy or peripheral neuropathy involving the lower extremities, cardiopulmonary disease which limited walking more than knee pain, knee instability defined as a report of knee buckling or locking within the past month of the study knee, major neurological deficit that affected gait, psychiatric illness that limited informed consent or Parkinsonism
- Women in pregnancy
- Wheel chair users
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT04352322
Start Date
January 1 2012
End Date
July 1 2016
Last Update
April 20 2020
Active Locations (1)
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1
TOP Pharm. & Medicalware
Taichung, Taiwan