Status:
UNKNOWN
Effect of PEEP Titration on the EELV Measured by the Nitrogen Dilution Technique in ARDS
Lead Sponsor:
Centre Hospitalier Intercommunal Aix-Pertuis
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Mechanical ventilation of the patient with acute respiratory distress syndrome is one of the first therapies.
Detailed Description
The application of positive end expiratory pressure is recommended but the question remains "How to set the best positive end-expiratory pressure (PEEP) level for each patient? ". Different titration ...
Eligibility Criteria
Inclusion
- Patients admitted to intensive care with a diagnosis of moderate to severe ARDS in accordance with the Berlin criteria, i.e. a PAFI \<200 and PEEP \>5cm H20 ratio
- Diagnosis of ARDS made within 72 hours
- Age over 18 years
- Informed consent of the patient and/or trusted person where applicable
Exclusion
- Start of mechanical ventilation more than 72 hours prior to inclusion.
- SDRA evolving for more than 72 hours
- Presence of major hemodynamic instability with mean blood pressure \<60mmhg, and/or heart rate \<45 bpm or \>150bpm with an increase in vasopressor amine dosage of more than 20% over the last 6 hours.
- Intracranial hypertension with CPP\<60mmhg
- Massive hemoptysis requiring immediate surgical or interventional radiology procedure
- Tracheal surgery (except intensive care tracheotomy) or sternotomy within the previous 15 days
- Trauma or surgery of the face in the previous 15 days.
- Deep vein thrombosis treated for less than 2 days
- Pacemaker implantation in the last 2 days
- Unstable fracture (spine, femur or pelvis)
- Respiratory reasons
- use of extracorporeal oxygenation
- nitric oxide
- pleural drainage system with bronchopleural gap
- pulmonary transplantation
- Poor respiratory tolerance per procedure with desaturation Spo2\<85%.
- Poor hemodynamic tolerability per procedure combining hypotension with MAP\<65mmhg and a 20% increase in norepinephrine dosage.
- Lack of patient consent to proceed
- minor patient
- lack of consent
Key Trial Info
Start Date :
January 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04352725
Start Date
January 20 2020
End Date
November 30 2020
Last Update
April 20 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre Hospitalier Intercommunal Aix-Pertuis
Aix-en-Provence, France, 13100