Status:
COMPLETED
Physiological Responses in Young and Older Adults During a Prolonged Simulated Heatwave
Lead Sponsor:
University of Ottawa
Conditions:
Aging
Heat Stress
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Climate change not only affects the planet's natural resources, but also severely impacts human health. An individual's ability to adequately cope with short- or long-term increases in ambient tempera...
Detailed Description
OBJECTIVES Intervention 1: Evaluate the effect of age on whole-body heat storage, body core temperature, and the development of cardiovascular strain and acute inflammation during day-long (9 hours) e...
Eligibility Criteria
Inclusion
- male or female (non-pregnant) adults with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis and or c) obesity as defined by the World Health Organization (Body Mass Index \[BMI\] greater than or equal to 30).
- non-smoking.
Exclusion
- Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).
- Serious complications related to your diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).
- Uncontrolled hypertension - BP \>150 mmHg systolic or \>95 mmHg diastolic in a sitting position.
- Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).
- Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.
- Cardiac abnormalities identified in your physical health screening form (adults \<65 years of age and older; adults \<60 years of age and older with diabetes and or hypertension) or during exercise stress testing as assessed by 12-lead (all adults ≥65 years of age and older).
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 2 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04353076
Start Date
January 1 2019
End Date
April 2 2021
Last Update
August 18 2021
Active Locations (1)
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1
University of Ottawa
Ottawa, Ontario, Canada, K1N6N5