Status:
COMPLETED
Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Gastroesophageal Reflux
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
To investigate the effect of citalopram, a selective serotonin reuptake inhibitor, on esophageal sensitivity.
Eligibility Criteria
Inclusion
- HV aged between 18 - 60 years
Exclusion
- history of psychiatric disease or a positive first degree psychiatric family history
- pregnancy or lactation
- concomitant administration of any centrally activating medication (anti-depressive medication, hypnotics, sedatives, anxiolytics, …)
- medication affecting esophageal motility
- significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary, endocrine, autoimmune, renal and hepatic)
- prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure
- history of gastrointestinal disease
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04355455
Start Date
July 1 2011
End Date
January 1 2012
Last Update
April 21 2020
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