Status:
COMPLETED
Sevoflurane in COVID-19 ARDS (SevCov)
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Kantonsspital Münsterlingen
Triemli Hospital
Conditions:
ARDS, Human
Coronavirus
Eligibility:
All Genders
18-85 years
Phase:
PHASE3
Brief Summary
The purpose of this trial is to study the effect of initial temporary sevoflurane sedation on mortality and persistent organ dysfunction (POD) in survivors at day 28 after ICU admission in the populat...
Detailed Description
The corona virus disease 19 (COVID-19) pandemic, caused by the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), is spreading rapidly across Europe. While data from European centers are s...
Eligibility Criteria
Inclusion
- SARS-CoV-2 infection (positive testing) or computed tomography (CT) scan-suspected COVID-19 ARDS
- Male and female patients, age 18 to 85 years
- ICU patients with ARDS defined as PaO2/FiO2 \< 200mmHg (=26.6kPa)
- Time of intubation not longer than 24 hours
- QTc Time (ECG) not longer than 470 ms ♂ (male)/ 480 ms ♀ (female)
- Sedation and mechanical ventilation in ICU
- Informed consent, signed by a representative or by an independent physician
Exclusion
- High dose systemic corticosteroids in the phase before hospitalization (\> 10mg/d prednisone or equivalent dose)
- Significant concomitant disease (acute cerebral vascular event, acute coronary syndrome, seizure, burn, neuromuscular disease)
- Organ transplant
- AIDS
- Pregnancy and/or breastfeeding
- Use of cytokine absorber
Key Trial Info
Start Date :
April 23 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 16 2021
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT04355962
Start Date
April 23 2020
End Date
July 16 2021
Last Update
July 19 2021
Active Locations (4)
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1
Kantonsspital Münsterlingen
Münsterlingen, Switzerland, 8596
2
Cantonal Hospital of St. Gallen
Sankt Gallen, Switzerland, 9007
3
Stadtspital Triemli
Zurich, Switzerland, 8063
4
University Hospital Zuirch
Zurich, Switzerland, 8091