Status:
UNKNOWN
Systematic Screening for Primary Immunodeficiencies in Patients Hospitalized for Severe Infections in Intensive Care.
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Primary Immunodeficiency
Eligibility:
All Genders
1-16 years
Brief Summary
Currently about 90 cases of infection in children are reported every year in pediatric intensive care, a disease considered to be the main cause of hospitalization of children. 16% of invasive pneumoc...
Detailed Description
Severe infection requiring admission in intensive care unit (ICU) are not so rare. A retrospective pilot study conducted at Montpellier University Hospital Center (UHC) between 2013 and 2015 showed th...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Subject aged 1 month to 16 years.
- Admission in pediatric ICU for more than 24h.
- Documented severe infection (bacterial, viral, fungal).
- Child benefiting from a social security scheme.
- Collection of parental consent / legal representatives.
- Exclusion criteria:
- Prematurity (gestational age \<37 weeks of gestation) up to 6 months of age.
- Undocumented severe infections.
- Children entered for isolated RSV bronchiolitis, with no other infectious related complications.
- Previous comorbidity explaining the infection and/or the stay in intensive care / continuous care: known primary or secondary immunodeficiency; burned; risk factors for status epilepticus (encephalopathy, known epilepsy, head trauma), pneumonia or asthma (swallowing disorders, tracheotomy, chronic pulmonary pathology, asthma), meningitis (cochlear implants, breccia, neuromeningeal material), deep infection (implanted material, recent surgery), cardiovascular decompensation.
- Any other chronic pathology favoring an infection
- Impossibility to obtain the consent of parents / legal representatives.
Exclusion
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2021
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04356053
Start Date
April 1 2020
End Date
December 30 2021
Last Update
October 12 2021
Active Locations (1)
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1
Uhmontpellier
Montpellier, France, 34295