Status:
NOT_YET_RECRUITING
Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection
Lead Sponsor:
Fujian Medical University
Conditions:
Multiple Organ Failure
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Multiple organ dysfunction syndrome (MODS) after surgical repaired for acute type A aortic dissection (ATAAD) is a life-threatening condition. In this study, patients who undergoing surgical repaired ...
Detailed Description
Multiple organ dysfunction syndrome (MODS) are common debilitating complications after surgical repaired for ATAAD. MODS is one of the chief causes of post-operative death for acute type A aortic diss...
Eligibility Criteria
Inclusion
- Part 1:
- Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft
- elder than 60 years old
- Preoperative PaO2/FiO2 ≥ 400mmHg, platelets ≥ 150\*109/L, bilirubin≥ 20μmol/L, no hypotension (without vasoactive drugs), Glasgow Coma Score Scale = 15, creatine ≥110μmol/L
- Part 2:
- Patients who are diagnosed with ATAAD and received emergency surgery with ascending aortic replacement combined with open placement of triple-branched stent graft
- Patients who have failure of at least 2 organs
- Patients who meet the criteria as below:
- sequential organ failure assessment score (SOFA) ≥ 10
Exclusion
- • uncontrollable underlying disease life expectancy of less than 4 days history of long-term corticosteroid use during the past 6 months.
- The pre-operative computer tomography angiography(CTA) demonstrate the visceral arteries are involved
- pre-existing severe disease of any major organs
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2030
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04356300
Start Date
September 1 2020
End Date
September 1 2030
Last Update
May 6 2020
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