Status:
UNKNOWN
Improving Treatment of Glioblastoma: Distinguishing Progression From Pseudoprogression
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Glioblastoma
Eligibility:
All Genders
18-80 years
Brief Summary
Glioblastoma is the most aggressive kind of brain cancer and leads on average to 20 years of life lost, more than any other cancer. MRI images of the brain are taken before the operation, and every fe...
Detailed Description
The impact of pseudoprogression is significant on patient care and medical research. The existing evidence shows that it is feasible to use Support Vector Machine and Deep Learning classification mode...
Eligibility Criteria
Inclusion
- Diagnosed with glioblastoma (World Health Organisation grade IV)
- Patient undergoing the standard Stupp treatment regimen
- Have had a pre-surgery scan and at least one follow-up scan post-chemoradiation
Exclusion
- Insufficient clinical and radiological follow-up
- The patient's treatment deviates greatly from the standard Stupp regimen, such as they are recruited into interventional trials and sufficient information is not known about the patient's trial treatment
- Patients receiving treatment with Angiogenesis inhibitors such as bevacizumab prior to completion of the Stupp regimen
Key Trial Info
Start Date :
March 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 26 2025
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04359745
Start Date
March 21 2019
End Date
May 26 2025
Last Update
April 21 2023
Active Locations (15)
Enter a location and click search to find clinical trials sorted by distance.
1
Royal Sussex County Hospital, Brighton and Sussex University Hospitals NHS Trust
Brighton, United Kingdom, BN2 5BE
2
Velindre Cancer Centre, Velindre University NHS Trust
Cardiff, United Kingdom, CF14 2TL
3
Ninewells Hospital and Medical School, NHS Tayside
Dundee, United Kingdom, DD1 9SY
4
Hull Royal Infirmary, Hull University Teaching Hospitals NHS Trust
Hull, United Kingdom, HU3 2KZ