Status:
UNKNOWN
High Pressure Non Invasive Ventilation in Hypercapnic Respiratory Failure
Lead Sponsor:
Assiut University
Conditions:
Acute Hypercapnic Respiratory Failure
Eligibility:
All Genders
18-75 years
Brief Summary
High pressure NIV is a pressure limited ventilation, stating IPAP pressure at 20 cmH2O and gradually increasing pressure up to 30 cmH2O according to patient tolerance.
Detailed Description
Noninvasive ventilation (NIV): refers to the administration of ventilatory support without using an invasive artificial airway (endotracheal tube or tracheostomy tube). NPPV is well established in the...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- All patients admitted in Assiut University Hospital and Assiut Police Hospital with acute hypercapnic respiratory failure due to COPD and Obesity hypoventilation syndrome (OHS) indicated for conventional NIV.
- Patients who failed on low pressure NIV will be shifted to high pressure NIV with any of these conditions:
- PH \<7.30 or less than admission level.
- RR \> 35b/m or more than admission level.
- SpO2 \< 88%.
- Exclusion criteria: (4)
- Age \<18 years.
- Excessive amount of respiratory secretions or weak cough.
- Upper airway obstruction.
- Recent oral, facial or cranial trauma or surgery.
- Sever abdominal distension.
- Active upper gastrointestinal bleeding.
- Cardiac or respiratory arrest.
- PH\<7.25.
- Arterial oxygen tension /fraction of inspired oxygen (PaO2 / FiO2) \<150mmHg.
Exclusion
Key Trial Info
Start Date :
August 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2023
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT04362787
Start Date
August 1 2020
End Date
April 1 2023
Last Update
July 13 2020
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