Status:
UNKNOWN
Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)
Lead Sponsor:
Louisiana State University Health Sciences Center in New Orleans
Collaborating Sponsors:
Lafayette General Health
University of Louisiana at Lafayette
Conditions:
COVID-19
Corona Virus Infection
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This a double-blind, randomized, placebo-controlled clinical trial to determine if primary prophylaxis with hydroxychloroquine in healthcare workers reduces symptomatic COVID-19 infection. Healthcare ...
Detailed Description
The study is a double blind placebo controlled at two hospitals in Lafayette, Louisiana aiming to enroll 1700 participants with a 1:1 randomization. The HCQ dose in 400mg twice on day 1, then 200mg tw...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Healthcare or Hospital Worker who has direct patient contact
- Willing to participate in the research.
- Able to understand and sign the informed consent form
Exclusion
- Age \< 18 years
- History of ventricular arrhythmia or use of Class IA, IC and III anti-arrhythmics
- Known prolonged QTc interval
- History of retinal disease
- Kidney failure with GFR \<10%
- Chronic hepatic disease w/ Child-Pugh class B or C
- Hypersensitivity to chloroquine or hydroxychloroquine
- Currently taking chloroquine or hydroxychloroquine
- Unwilling to participate
- Unable to understand and/or sign the informed consent form.
Key Trial Info
Start Date :
April 27 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
1700 Patients enrolled
Trial Details
Trial ID
NCT04363450
Start Date
April 27 2020
End Date
June 1 2021
Last Update
September 2 2020
Active Locations (2)
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1
Lafayette General Medical Center
Lafayette, Louisiana, United States, 70503
2
University Hospital and Clinics
Lafayette, Louisiana, United States, 70506