Status:
UNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.
Lead Sponsor:
Aristotle University Of Thessaloniki
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
Up to 16 years
Brief Summary
Haematological malignancies constitute the most common neoplastic disease in child population, with acute leukemia occupying the number one spot with a percentage of 32.8%. In children, leukaemia is p...
Detailed Description
Introduction Malignancies during childhood constitute the 2nd cause of death, following injuries worldwide. According to epidemiological data, 300,000 new cases of neoplasia present themselves every ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Children and adolescents newly diagnosed with acute lymphoblastic leukaemia. A complete personal and family history will be recorded for each participant from every group with particular emphasis on the presence of dyslipidaemia, early cardiovascular disease or cerebrovascular accident in the individual or in the family. A thorough clinical examination will be performed and the vital signs, blood pressure, weight (kg), height (m) and a Body/Mass Index (BMI) will be recorded and calculate.
- The Exclusion criteria are the following:
- Thyroid Disorder (Abnormal thyroid function)
- Familial Hypercholesterolemia
- High Body/ Mass Index (BMI)
- Administration of corticosteroids some time during the past 2 weeks before diagnosis
- Administration of total parenteral nutrition before the diagnosis
- Administration of plasma before the diagnosis
- Changes or variation of the parameters under study before the start of treatment and the 11th day (before the start of asparagine administration).
Exclusion
Key Trial Info
Start Date :
September 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04364451
Start Date
September 1 2019
End Date
August 31 2022
Last Update
April 28 2020
Active Locations (1)
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1
Paediatric and Adolescent Haematology-Oncology Unit, 2nd Department of Paediatrics, Aristotle University of Thessaloniki (AUTH), University General Hospital AHEPA
Thessaloniki, Greece, 54636