Status:
COMPLETED
Speech Entrainment for Aphasia Recovery
Lead Sponsor:
Medical University of South Carolina
Collaborating Sponsors:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Aphasia
Aphasia Non Fluent
Eligibility:
All Genders
21-81 years
Phase:
PHASE2
Brief Summary
After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Aphasia as a result of a left hemisphere ischemic or hemorrhagic stroke (WAB-R Aphasia Quotient \<93.8).
- Presence of left hemisphere stroke in clinical imaging (CT/MRI) and NIHSS
- Participants must have spoken English as their primary language.
- 21-81 years old
- Pre-stroke modified Rankin Scale (mRS)= 2 or less
- Post-stroke mRS= 4 or less.
- At least 6 months post-stroke.
- Non-fluent aphasia (WAB-R Comprehension score \>4 and WAB-R Fluency score \<6).
- Technological compatibility (to be determined by clinical judgment of SLP)
- Exclusion Criteria
- History of chronic neurological or psychiatric diseases (excluding migraines, depression, or post-stroke epilepsy). Self-reported history of learning disability.
- Severe dysarthria (determined via SLP clinical judgment from spontaneous speech tasks on the ASRS 3.0).
- Global aphasia.
- History of right-hemisphere strokes or brain stem/cerebellar strokes with persistent deficits (as evidenced by MRI/CT and NIHSS).
- Uncorrectable hearing as determined by the SLP's clinical judgment.
- Uncorrectable vision.
- Contraindications to MRI or inability to complete the MRI scanning session.
- Women who are pregnant.
Exclusion
Key Trial Info
Start Date :
August 21 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04364854
Start Date
August 21 2020
End Date
August 31 2025
Last Update
November 14 2025
Active Locations (3)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29401
2
University of South Carolina
Columbia, South Carolina, United States, 29208
3
University of Utah
Salt Lake City, Utah, United States, 84112