Status:
RECRUITING
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Hallucinations, Auditory
Psychosis
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have ...
Detailed Description
Auditory verbal hallucinations (AVH) are present throughout the course of psychotic illness and are among its most distressing symptoms. The presence of hallucinations alone increases risk of suicide ...
Eligibility Criteria
Inclusion
- Age 18-65
- English speaking
- Right handedness
- Diagnosed with schizophrenia schizoaffective, schizophreniform, schizotypal, or brief psychotic disorder
- History of auditory verbal hallucinations occurring at least weekly
Exclusion
- Current substance dependence or active use as determined by drug test.
- Any neurological, medical or developmental problem that is known to impair cognition significantly
- Contraindications for MR scanning including metallic implants of any kind, pacemakers and history of accidents with metal, claustrophobia
- History of seizures
- History of violence
- History of suicide
- Pregnancy (determined by urine pregnancy test)
- Concurrent participation in any other intervention study
- History of urinary retention
- History of delirium
- Current use of any cholinergic or anticholinergic medication
- History of asthma, diabetes, and cardiovascular disease
- Evidence of cardiovascular disease on EKG
- Individuals who have been on dopamine-2 antagonists for less than 6 months (to limit risk of EPS)
Key Trial Info
Start Date :
July 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2032
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT04366518
Start Date
July 15 2021
End Date
August 1 2032
Last Update
June 5 2025
Active Locations (1)
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1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519