Status:
UNKNOWN
Clinical Pharmacokinetic Study of Ceftazidime and Cefazolin
Lead Sponsor:
Fifth Affiliated Hospital, Sun Yat-Sen University
Conditions:
CAPD-related Peritonitis
Eligibility:
All Genders
15-70 years
Brief Summary
Peritoneal dialysis-related peritonitis is a common complication of peritoneal dialysis, which is the main cause of transfer from peritoneal dialysis to hemodialysis. Guidelines for International Soci...
Detailed Description
The dose of cefazolin and Ceftazidime co-administered were 20 mg /kg，they were given intraperitoneal twice daily in the first bag and the fourth bag for 5 days，and given 1g once daily in the fourth ba...
Eligibility Criteria
Inclusion
- Maintained on continuous ambulatory PD (CAPD) for at least 1 month,all patients received 4 exchanges per day with dialysate volumes of 2 L per exchange.
- The diagnostic criteria for CAPD-related peritonitis are as follows:
- The dialysate fluid appears cloudy and accord with the following peritonitis diagnostic criteria: (with the following two can be diagnosed) A. Clinical manifestations of peritoneics, such as abdominal pain and/or turbid flow of fluid from peritoneal dialysis; B. Perital dialysis discharge of liquid pathogen culture positive. C. The white blood cell count of perital dialysis outflow liquid were more than 0. 1 x 10 x 9/L, and the percentage of polymorphic nucleocells is more than 50% (peritoneal dialysis fluid remains in the abdominal cavity for at least 2 hours for more than 2 hours);
- No urine (less than 100ml per 24h).
- Age range form 15 years old to 70 years old, gender is not limited;
- Understand and agree to this clinical trial study.
Exclusion
- With a clear history of cephalosporine drug allergy or hypersensitivity;
- Received antibiotic treatment within 1 week prior to entering the study;
- Pregnant and lactating women;
- Sepsis;
- Patients with celiac malignancy;
- The patient is unable to cooperate or unwilling to accept the test.
Key Trial Info
Start Date :
June 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04367974
Start Date
June 1 2020
End Date
May 1 2022
Last Update
May 21 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
the fifth affiliated hospital of SUN YAT-SEN university
Zhuhai, Guangdong, China, 519000