Status:
COMPLETED
Hepassocin Levels in Patients With Polycystic Ovary Syndrome
Lead Sponsor:
Fatma ketenci gencer
Conditions:
Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1)
Polycystic Ovary Syndrome
Eligibility:
FEMALE
18-35 years
Brief Summary
The investigators aimed to investigate hepassocin levels in patients with polycystic ovary syndrome (PCOS). There are 3 groups aged between 18 and 35 years as non-obese healthy women, non-obese women ...
Detailed Description
Hepassocin, also known as Fibrinogen-like-protein or hepatocyte-derived fibrinogen-related protein 1, is a new marker for obesity and insulin resistance. In hepatic injury, it protects liver cells and...
Eligibility Criteria
Inclusion
- 60 patients with PCOS aged between 18 and 35 and age-matched 30 healthy women with BMI\<30
Exclusion
- Premature ovarian failure (FSH \>30 mIU/mL), tumors secreting androgens, non-classical congenital adrenal hyperplasia, Cushing syndrome and irregular menses due to thyroid dysfunction (TSH \>5 mIU/L ), hyperprolactinemia, more than twofold high transaminase levels (\>70 U/L), patients with cigarette smoking, alcohol consumption, oral contraceptives use, medications that are affecting liver function test, insulin metabolism and lipid metabolism, patients with a history of chronic diseases such as diabetes mellitus, hypertension, chronic liver disease, chronic kidney disease, autoimmune disease, inflammatory disease, malignant disease, bleeding disorders, and thrombosis were also excluded. All the patients were beta-HCG, hepatitis B surface antigen, and hepatitis C antibody negative.
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Key Trial Info
Start Date :
January 3 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 25 2020
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04369248
Start Date
January 3 2020
End Date
March 25 2020
Last Update
April 30 2020
Active Locations (1)
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1
Gaziosmanpasa Taksim Education and Research Hospital
Istanbul, Turkey (Türkiye)