Status:
WITHDRAWN
BAFF Levels and Lupus Nephritis (LN)
Lead Sponsor:
Universidad de Antioquia
Collaborating Sponsors:
ARTMEDICA
Conditions:
Lupus Nephritis
Eligibility:
FEMALE
18+ years
Brief Summary
B-cell activating factor (BAFF), serves as a vital survival and differentiation factor for normal B-cell development. BAFF levels have been associated with the clinical activity of SLE in humans. BAFF...
Detailed Description
1.3. Research question Flares of lupus nephritis are related to the behavior of BAFF levels before, during, and after induction therapy. 2\. Theoretical framework B-cell activating factor (BAFF), als...
Eligibility Criteria
Inclusion
- Patients are older than 18 years
- Patients that fulfill any of the available classification criteria for systemic lupus erythematosus
- Patients with new-onset lupus nephritis or with lupus nephritis relapse after successful remission.
- Patients with a diagnosis of lupus nephritis according to Wallace and Dubois criteria
- Patients with class III and IV lupus nephritis with or without Class V lupus nephritis.
Exclusion
- Women with a positive pregnancy test
- Class I, II, V lupus nephritis without Class III or IV lupus nephritis
- Patients with an active malignancy or active treatment for malignancy.
- Patients with kidney disease with GFR \<30ml / min
- Patients with severe leukopenia
- Patients with active infection
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04369495
Start Date
January 1 2021
End Date
January 1 2023
Last Update
May 13 2024
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