Status:
UNKNOWN
Renin-Angiotensin-Aldosterone System Inhibitors, Hypertension, and COVID-19
Lead Sponsor:
Versailles Hospital
Collaborating Sponsors:
Bernard LIVAREK, MD, Cardiology department, Versailles Hospital
Jean-Paul BERESSI, MD, Department of diabetology, Versailles Hospital
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Brief Summary
Background. Angiotensing converting enzyme type 2 (ACE2), a key enzyme of the renin-angiotensin-aldosterone system (RAAS), is the receptor of SARS-CoV-2 for cell entry into lungs. Because ACE2 may be ...
Detailed Description
The coronavirus disease 2019 (Covid-19) pandemic is currently the main challenge facing healthcare providers. Data are lacking to guide clinical decision. The renin-angiotensin-aldosterone system (RA...
Eligibility Criteria
Inclusion
- Age equal or more than 18;
- Symptoms suggestive of Covid-19 pneumonia. At least : fever \> 38°C or influenza-like illness (asthenia, myalgia, chills, muscular aches, …) AND cough or dyspnea;
- Hospitalization required on clinical criteria including: oxygen saturation \<96% without oxygen support, respiratory frequency \> 25 per minute, hemodynamic instability, medical history or comorbidities known at high risk for Covid-19 (chronic heart disease, congestive heart failure, chronic bronchopulmonary disease, diabetes mellitus, age\>70, history of cancer, immunosuppression, …);
- Covid-19 confirmation test performed (RT-PCR).
Exclusion
- Age \< 18
- Refusal to participate in the study
- detainee or prisoner
- Protected adult uncapable to consent
Key Trial Info
Start Date :
May 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2020
Estimated Enrollment :
700 Patients enrolled
Trial Details
Trial ID
NCT04374695
Start Date
May 1 2020
End Date
July 1 2020
Last Update
May 5 2020
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