Status:
RECRUITING
Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma
Lead Sponsor:
Cancer Hospital of Guangxi Medical University
Conditions:
Recurrent Nasopharyngeal Carcinoma
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
This is a phase 3, multicentre, randomised controlled trial to study the effectiveness and toxicity of PD-1 antibody Toripalimab combined with concurrent cisplatin chemoradiotherapy versus cisplatin c...
Detailed Description
Nasopharyngeal carcinoma (NPC) is endemic in southern China, southeast Asia, and northern Africa. According to a survey from the International Agency for Research on Cancer, there were an estimated 12...
Eligibility Criteria
Inclusion
- Patients with newly histologically confirmed recurrent nasopharyngeal carcinoma, or Two or more image examinations (MRI, and PET-CT) show the recurrent tumor
- staged as rT3-4N0-1M0或rT1-4N2-3M0 （according to the 8th AJCC edition）
- Satisfactory performance status: ECOG (Eastern Cooperative OncologyGroup) scale 0-1
- Neutrophil ≥ 1.5×109 /L and PLT ≥4×109 /L and HGB ≥90 g/L
- With normal liver function test (ALT、AST ≤ 2.5×ULN, TBIL≤ 1.5×ULN)
- With normal renal function test ( creatinine clearance ≥60 ml/min)
- sign an "informed consent form
- Male and no pregnant female
Exclusion
- Age older than 65, or younger than 18 years old
- Hepatitis B surface antigen (HBsAg) positive and HBV-DNA ≥200IU/ml, or 1000cps/ml.
- Patients with positive HCV antibody.
- Active, known or suspected autoimmune disease; Type I Diabetes, hypothyroidism those only need hormone replacement therapy, and skin disease (leukoderma, psoriasis, alopecia et al) who don't need systemic therapy can recruit.
- History of interstitial lung disease
- Equivalent dose more than prednisone 10mg/d or other immunosuppressive treatments within 28 days prior to signing the informed consent.
- Receive or will receive live vaccine within 30 days prior to signing the informed consent.
- Women of child-bearing potential who are pregnant or breastfeeding.
- Suffered from malignant tumors, except the carcinoma in situ, papillary thyroid carcinoma, or skin cancer (non- melanoma) within five years.
- Hypersensitivity to macromolecular protein, or to any component of triplezumab.
- HIV positive.
- Severe, uncontrolled medical conditions and infections.
- Other diseases which may influence the safety or compliance of the clinical trial, such as heart failure with symptom, unstable angina, myocardial infarction, active infections those need systemic therapy, mental illness, or their family and society factors.
Key Trial Info
Start Date :
June 28 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2028
Estimated Enrollment :
204 Patients enrolled
Trial Details
Trial ID
NCT04376866
Start Date
June 28 2020
End Date
April 1 2028
Last Update
July 20 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Guangxi Medical University Cancer Hospital
Nanning, Guangxi, China, 530021