Status:
COMPLETED
Acute Impact of Cardiac Resynchronization on Vascular Function (RVA-CRT)
Lead Sponsor:
Andreas Flammer
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Evaluation of the effect of short term activation/deactivation of biventricular pacing (BivP) of the CRT (during routine CRT interrogation) on vascular function as assessed via retinal vessel analysis...
Detailed Description
Heart failure is a condition in which the heart becomes unable to maintain the body's need of blood supply. Congestive heart failure can be considered a syndrome but the final common path of many card...
Eligibility Criteria
Inclusion
- Informed Consent as documented by signature
- Patients ≥ 18 years of age, male or female, diagnosed with advanced heart failure
- Implanted as well as activated CRT device for at least 3 months prior to Visit 1
Exclusion
- Current acute decompensated HF
- Documented pacing dependency
- Documented AV-Block II (Mobitz Typ 2) or III in patient's history
- History of hypersensitivity or allergy to Tropicamide
- Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or other major cardiovascular (CV) surgery, percutaneous coronary intervention (PCI) or carotid angioplasty within 3 months prior to Visit 1.
- History of heart transplant, on a transplant list or with ventricular assistance device (VAD).
- Presence of any other disease with a life expectancy of \< 6 months
- Presence of significant endocrine diseases, including primary hyperparathyroidism, Cushing's disease, adrenal insufficiency, pituitary tumors, primary hyperaldosteronism, manifest hyperthyroidism or genetic endocrine disorders
- Presence of active acute infectious diseases.
- Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc
- Women who are pregnant or breast feeding
- Known narrow-angle glaucoma
- Known epilepsy (flicker-light could trigger a seizure)
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 20 2023
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT04379401
Start Date
January 1 2021
End Date
June 20 2023
Last Update
August 1 2023
Active Locations (1)
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1
UniversitätsSpital Zürich
Zurich, Switzerland, 8091