Status:
COMPLETED
Biomechanical and Neural Mechanisms of Post-stroke Gait Training
Lead Sponsor:
Emory University
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Stroke
Eligibility:
All Genders
35-90 years
Phase:
NA
Brief Summary
The study seeks to develop an understanding of how, why, and for whom fast treadmill walking (Fast) and Fast with functional electrical stimulation (FastFES) induce clinical benefits, allowing future ...
Detailed Description
Stroke is the leading cause of adult disability in the United States, with stroke prevalence expected to increase by 20% in the next 20 years. Stroke induces a cascade of neurophysiologic changes in c...
Eligibility Criteria
Inclusion
- at least 6 months since stroke
- single cortical or subcortical ischemic stroke
- able to walk 10-meters with or without assistive device
- sufficient cardiovascular health and ankle stability to walk on treadmill for 2-minutes at self-selected speed without orthosis
- resting heart rate 40-100 bpm
Exclusion
- hemorrhagic stroke
- cerebellar signs (ataxic ("drunken") gait or decreased coordination during rapid alternating hand or foot movements
- score of \>1 on question 1b and \>0 on question 1c on NIH Stroke Scale
- inability to communicate with investigators
- musculoskeletal conditions or pain that limit walking
- neglect/hemianopia, or unexplained dizziness in last 6 months
- neurologic conditions or diagnoses other than stroke
- lack of sensation in lower limb affected by stroke
- any medical diagnosis that would hinder the participant from completing the experimental trial
- additional exclusion criteria due to contra-indications to TMS (measurement of corticospinal excitability) are: history of seizures, metal implants in the head or face, history of recurring or severe headaches/migraine, headache within the past 24 hours, presence of skull abnormalities or fractures, hemorrhagic stroke, history of dizziness, syncope, nausea, or loss of consciousness in the past 6 months
Key Trial Info
Start Date :
March 16 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2025
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT04380454
Start Date
March 16 2021
End Date
October 1 2025
Last Update
December 11 2025
Active Locations (1)
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1
Emory University Hospital
Atlanta, Georgia, United States, 30322