Status:
UNKNOWN
Efficacy and Safety of Two Regimens of Anti-VEGF Therapy in Chinese Patients With Polypoidal Choroidal Vasculopathy
Lead Sponsor:
Xiaodong Sun
Collaborating Sponsors:
Eye & ENT Hospital of Fudan University
Shanghai Zhongshan Hospital
Conditions:
Polypoidal Choroidal Vasculopathy
Eligibility:
All Genders
50+ years
Phase:
PHASE4
Brief Summary
The study will evaluate the efficacy and safety of two different regimens of anti-VEGF Therapy (OCTA plus OCT guided 3+PRN vs. OCT guided 3+PRN) in Chinese patients with PCV. This study is to provide ...
Eligibility Criteria
Inclusion
- Written informed-consent before any evaluation
- Visual impairment due to PCV, including type 1 PCV and type 2 PCV.
- 50 years old and older
- Chinese
- For study eye: BCVA between 20/30 and 20/320 on electronic visual acuity texting at the time point of both screening and baseline.
Exclusion
- Have Stroke and myocardial infarction within 3 months before screening
- Any active periocular and ocular infection and inflammation (including blepharitis, conjunctivitis, keratitis, scleritis, uveitis, intraocular inflammation) while screening and baseline.
- Uncontrolled glaucoma (under treatment \[IOP\] ≥ 30 mm Hg or depend on researchers) while screening and baseline
- Neovascularization of iris and neovascular glaucoma while screening and baseline
- Any causes led to choroidal neovascularization except PCV (including ICNV, central serous chorioretinopathy, ocular histoplazmoza and pathologic myopia) while screening and baseline
- With structure injury (including vitreous macular traction,epiretinal membrane involving in central fovea,subretinal fibroplasia,laser scar and central fovea atrophy) within 0.5 optic disc diameter to the central of macula while screening and baseline, which may harm the improvement of vision by treatment according to researchers
- Any systemic anti-VEGF medication(as Avastin) use within 3 months before screening
- Any medication systemic use toxic to lens, retina and optic nerve, including iron amine, chloroquine/chloroquine (Plaquenil ®), tamoxifen, phenothiazine and ethambutol
- For study eye: Used to accept following treatments for PCV within 3 months or accept following treatments more than three times before baseline:
- Anti-angiogenesis drugs (pegaptanib, ranibizumab, bevacizumab),VEGF-Trap;
- Anecortave acetate corticosteroids;
- Protein kinase C inhibitors, squalamine, siRNA;
- PDT, Visudyne® treatment, external beam radiotherapy, local laser photocoagulation, vitrectomy, submacular surgery and transpupillary thermotherapy
- Any intraocular surgery (including YAG laser) within 3 months before baseline or predicated within 6 months after baseline
- Intraocular or periocular treatment of corticosteroids within 3 months before baseline
- For follow eye: Any anti-angiogenesis treatment (including anti-VEGF, like Lucentis, Avastin and KH902 ) within 3 months before baseline
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT04380974
Start Date
June 1 2020
End Date
September 1 2022
Last Update
May 8 2020
Active Locations (1)
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1
Shanghai General Hospital, Shanghai Jiao Tong University
Shanghai, China, 200080