Status:
RECRUITING
ASPIrin in Reducing Events in Dialysis ( ASPIRED )
Lead Sponsor:
Guangdong Provincial People's Hospital
Collaborating Sponsors:
The George Institute
Conditions:
CKD (Chronic Kidney Disease) Stage 5D
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population. A cardiac cause accounts for 58% of all deaths in ...
Detailed Description
ASPIRED is an investigator-initiated, multi-center, double-blind, parallel group, event-driven, pragmatic, registry-based randomized controlled trial that will define the value of low dose aspirin (10...
Eligibility Criteria
Inclusion
- Incident or prevalent adults (≥18 years old) dialysis patients are included in the Dialysis Registry.
- Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement.
- Willing and able to provide informed consent for this study.
Exclusion
- Requirement for any form of antiplatelet agent (aspirin, glycoprotein IIb/IIIa inhibitors etc), or oral anticoagulation (warfarin, NOACs), in the view of the treating physician.
- Contraindication to aspirin, in the view of the treating physician.
- Dialysis requirement due to acute kidney injure with expectation of kidney function recovery.
- History of haemorrhagic stroke or intracranial bleed within 12 months of screening.
- Coagulopathy from any cause.
- Unable to provide informed consent.
Key Trial Info
Start Date :
July 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
9000 Patients enrolled
Trial Details
Trial ID
NCT04381143
Start Date
July 30 2020
End Date
December 1 2026
Last Update
November 18 2025
Active Locations (139)
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1
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
2
Shanghang County Hospital
Longyan, Fujian, China, 364299
3
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
4
Dongguan Donghua Hospital
Dongguan, Guangdong, China, 523413