Status:
UNKNOWN
Hypertonic Saline Nasal Irrigation and Gargling in Suspected or Confirmed COVID-19 (ELVIS COVID-19)
Lead Sponsor:
University of Edinburgh
Conditions:
Upper Respiratory Tract Infections
Virus
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
ELVIS COVID-19 is a pragmatic web-based Bayesian adaptive randomised controlled, parallel group trial of hypertonic saline nasal irrigation and gargling (HSNIG) compared to standard care in participan...
Detailed Description
COVID-19, a recently identified disease, has spread worldwide rapidly and is now a pandemic. There is no cure for it yet. Though it causes mild to moderate illness in most people, it can cause serious...
Eligibility Criteria
Inclusion
- Adults (≥18 years)
- Those living within the UK
- Those self-isolating at home within 48 hours of the start of the illness with:
- Clinical symptoms suggestive of COVID-19 (i.e. those who have at least one of the following symptoms: recent onset of (i) new continuous cough and/or (ii) high temperature) and/or (iii) loss of, or change in, sense of smell or taste (anosmia) OR
- Those with virologically confirmed SARS-CoV-2 infection and clinical symptoms indicative of COVID-19 (as detailed in (a) above).
- Provision of informed consent
Exclusion
- Onset of illness\>48 hours
- Inability to consent
- Pregnancy
- Immunosuppression
- Inability to perform HSNIG
- Those taking part in another interventional medical trial
- Those without access to a supply of salt
- Those who have had a negative COVID-19 swab result for the present symptoms
- Those with suspected/confirmed COVID-19 in whom hospital admission is recommended
- Those who do not have access to email/internet
- Those living in a household with another person currently participating in this study
Key Trial Info
Start Date :
June 23 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2020
Estimated Enrollment :
405 Patients enrolled
Trial Details
Trial ID
NCT04382131
Start Date
June 23 2020
End Date
October 31 2020
Last Update
September 2 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
NHS Lothian
Edinburgh, United Kingdom