Status:
COMPLETED
Targeting Hyaluronan Accumulation Through Exercise in T2DM
Lead Sponsor:
NYU Langone Health
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
A pilot longitudinal study to examine hyaluronan (HA) accumulation in muscles of individuals with Type 2 diabetes mellitus (T2DM), and the effects of exercise on HA accumulation, muscle stiffness, str...
Detailed Description
This single-center, longitudinal design study uses MRI to evaluate the mechanistic effects of exercise on skeletal muscle function. Twenty-five T2DM patients will be enrolled and be prescribed a 10-we...
Eligibility Criteria
Inclusion
- Be between the ages of 40 and 75
- Clinical diagnosis of Type 2 diabetes
- Have a BMI less than 40 kg/m2 (due to magnet bore restrictions)
- Able to walk unassisted
Exclusion
- Serious cardiac pathology or musculoskeletal problems that would limit exercise ability
- Current open wound or history of plantar ulcer for the last 3 months
- Partial foot amputations
- Inability to ambulate without assistive device
- Stroke or other central nervous system pathology
- Stage 2 hypertension (resting blood pressure \>160 systolic or \>100 diastolic)
- Contraindications to 3T whole body MRI scanners (e.g., pacemaker, cerebral aneurysm clip, cochlear implant, presence of shrapnel in strategic locations, metal in the eye, claustrophobia, or other problems).
- Subjects with alcoholism, chronic drug use, chronic gastrointestinal disease, or renal or hepatic impairment
- Pregnant women and children
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04383314
Start Date
September 1 2021
End Date
August 31 2024
Last Update
January 31 2025
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016