Status:
UNKNOWN
To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR
Lead Sponsor:
Guangzhou First People's Hospital
Conditions:
GH
Poor Ovarian Reserve Based on POSEIDON
Eligibility:
FEMALE
20-40 years
Brief Summary
It is still a big difficult clinical problem for patients with poor ovarian reserve undergoing in vitro fertilization. The decrease in both quality and quantity of egg are the main cause for poor clin...
Eligibility Criteria
Inclusion
- For patients with poor ovarian response, the criteria is based on POSEIDON criteria\[1\]:
- low ovarian reserve(AMH \<1.2ng/ml, or AFC \<5);
- younger than 40.
- For patients with normal ovarian reserve, the criteria is as follow:
- Patients who are between 20-40 years old;
- clinical diagnosis of non-functional fallopian tube;
- regular menstrual cycles.
Exclusion
- BMI ≥28kg/m2;
- medical diseases such as endocrine and metabolic diseases, autoimmune disease, etc;
- ovarian neoplasm that ≥4 cm in diameter and has no clear pathological diagnosis by surgery;
- adenomyosis or endometriosis confirmed by surgery;
- untreated abnormal intrauterine environment, such as uterine effusion, endometritis, etc;
- untreated hydrosalpinx;
- polycystic ovary syndrome.
Key Trial Info
Start Date :
May 26 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04384744
Start Date
May 26 2020
End Date
November 30 2021
Last Update
May 21 2020
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