Status:
RECRUITING
Cannabis Effects as a Function of Sex
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Pain
Abuse, Drug
Eligibility:
All Genders
21-55 years
Phase:
PHASE1
Brief Summary
The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
Detailed Description
The proposed study will compare smoked cannabis's dose-dependent, analgesic and abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharm...
Eligibility Criteria
Inclusion
- Male or non-pregnant female aged 21-55 years
- Report use of cannabis an average of 1-7 days per week
- Not currently seeking treatment for their cannabis use
- Urine test positive for recent cannabis use for heavy users
- No reported adverse effects with cannabis smoking in light users
- Have a Body Mass Index from 18.5 - 34kg/m2.
- Able to perform all study procedures
- FEMALES: Currently practicing a non-hormonal effective form of birth control
- FEMALES: Must be regularly cycling
Exclusion
- Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or cannabis use disorder
- Report using other illicit drugs in the prior 4 weeks
- History or current evidence of severe psychiatric illness or medical condition judged by the study physician and PI to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
- Current use of medical cannabis, prescription analgesics, or any medications that may affect study outcomes
- Current pain
- Insensitivity to the cold water stimulus of the Cold Pressor Test
- FEMALES: using a hormonal contraceptive
Key Trial Info
Start Date :
July 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT04385082
Start Date
July 8 2021
End Date
June 30 2026
Last Update
May 13 2025
Active Locations (1)
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1
University of California, Los Angeles
Los Angeles, California, United States, 90095