Status:
WITHDRAWN
#StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19
Lead Sponsor:
Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
BACKGROUND Despite drastic quarantine measures, COVID-19 continues to propagate and threatens global healthcare systems by saturating their capacity with high transmissibility and the particularly pro...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA (index cases):
- Age \>=18 years old AND
- SARS-CoV-2 positive AND
- Well enough to self-isolate at home (at an address in Switzerland) AND
- At risk of complications from COVID-19 i.e. one or more of the following
- Age \>=65 years
- Hypertension
- Diabetes
- Cardiovascular disease (History of infarction OR peripheral arteriopathy OR cerebrovascular accident OR cardiac insufficiency)
- Chronic respiratory disease
- Immunosuppression
- Cancer
- Obesity (BMI\>40)
- EXCLUSION CRITERIA (index cases):
- Allergy to hydroxychloroquine/4-aminoquinilones
- Retinal eye disease
- Known chronic kidney disease, stage 4 or 5 or receiving dialysis
- Weight \< 40 kg
- Known porphyria
- Known psoriasis
- Known myasthenia gravis
- Taking drugs with moderate-severe interactions with HCQ
- Taking ≥ 2 QT prolonging drugs
- Taking 1 QT prolonging drug AND a loop diuretic
- Moderate or severe heart failure
- Severe or uncontrolled arrhythmia
- Recent myocardial infarction or stroke (past 6 months)
- Current pregnancy
- Current hospitalisation
- Known hemolytic anaemia
- INCLUSION CRITERIA (household contacts):
- Age \>1 year old AND
- Living in same household as index case during self-isolation
- EXCLUSION CRITERIA (household contacts):
- History of laboratory-confirmed SARS-CoV-2 infection
Exclusion
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04385264
Start Date
January 1 2022
End Date
December 1 2022
Last Update
January 7 2025
Active Locations (1)
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1
Unisanté
Lausanne, Canton of Vaud, Switzerland, 1015