Status:
WITHDRAWN
PROphylaxis for paTiEnts at Risk of COVID-19 infecTion
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Collaborating Sponsors:
University of Cambridge
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The PROTECT open-label randomised basket trial will assess the effectiveness of hydroxychloroquine (HCQ) as chemoprophylaxis against COVID-19 in multiple vulnerable populations in the United Kingdom.
Detailed Description
COVID-19 (novel coronavirus-induced disease) was declared a global pandemic by the WHO on 11th March 2020. Currently there are no drugs proven to treat or delay progression of COVID-19 and no vaccine ...
Eligibility Criteria
Inclusion
- Have no previous confirmed COVID-19 diagnosis
- Fall into one of the high risk population groups
Exclusion
- Inability to provide informed consent
- Symptomatic for possible COVID-19 at baseline or symptoms highly suggestive of COVID-19 experienced since 1st March 2020
- Hypersensitivity reaction to hydroxychloroquine, chloroquine or 4-aminoquinolines or any formulation excipients
- Contraindication to taking hydroxychloroquine as prophylaxis e.g known epilepsy
- Already taking chloroquine, hydroxychloroquine or 4-aminoquinolines
- History of any retinopathy including diabetic retinopathy requiring laser therapy
- Taking medications which are contra-indicated alongside HCQ - Digoxin, Halofantrine, Amiodarone, Moxifloxacin, Cyclosporin, Mefloquine, Praziquantel, Tamoxifen
- Known history of prolonged QTc
- Type I diabetes or insulin-dependent type II diabetes
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04389359
Start Date
September 1 2020
End Date
August 1 2025
Last Update
March 8 2021
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.