Status:
COMPLETED
PS128 May Improve Off Duration on Parkinson's Disease
Lead Sponsor:
Professor Lu Neurological Clinic
Conditions:
Parkinson Disease
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the short term effects (12 Weeks) of Lactobacillus plantarum PS128 (PS128) on Parkinson's disease (PD) symptoms.
Detailed Description
This study is designed to examine the extent to which L. plantarum PS128 can improve symptoms in PD patients. L. plantarum PS128 is a psychobiotic that regulates the level of dopamine in specific brai...
Eligibility Criteria
Inclusion
- Patients diagnosed with idiopathic Parkinson's Disease
- According to the record of ON / OFF diary for 3 consecutive days, the patient's daily off periods must be more than 3 hours a day.
- Between ages of 40-80 years old.
Exclusion
- Patients on antibiotics within the preceding one month
- Patients using of other probiotic products (sachet, capsule or tablet) within the preceding two weeks
- Have undergone surgery of liver, bladder, or gastrointestinal tract
- Have current or history of inflammatory bowel disease
- Have history of cancer
- Known allergy to probiotics
- Patients with comorbid dementia (Mini-Mental State Examination score ≤ 26) or major depression (The Beck Depression Inventory-II score ≥ 29)
- Have received deep brain stimulation
- Patients receiving artificial enteral or intravenous nutrition
Key Trial Info
Start Date :
June 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 13 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT04389762
Start Date
June 4 2019
End Date
June 13 2020
Last Update
August 17 2025
Active Locations (1)
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1
Professor Lu Neurological Clinic
Taoyuan, Guishan Dist., Taiwan, 333