Status:
RECRUITING
Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Group 1: Healthy Controls
Group 2: Stable CF
Eligibility:
All Genders
4-18 years
Brief Summary
This is a prospective, longitudinal observational study conducted at The Hospital for Sick Children (SickKids). The purpose of this study is to evaluate the ability of MRI to detect changes in lung st...
Eligibility Criteria
Inclusion
- Participants must be greater than or equal to 4 years of age
- Informed consent by patient or parent/guardian consent and participant assent when appropriate.
- Able to perform reproducible spirometry and achieve a breath hold duration sufficient for MRI acquisition
Exclusion
- Medical instability that would preclude the ability to undergo the required investigations
- FEV1 % predicted \< 40%
- Severe claustrophobia
- Does not meet MRI screening criteria
- Cough within the past 3 days prior to study visit
- Usage of oral antibiotics within 3 weeks prior to study visit
Key Trial Info
Start Date :
October 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT04391322
Start Date
October 20 2020
End Date
December 1 2025
Last Update
November 12 2024
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8