Status:
UNKNOWN
Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Cardiopulmonary Resuscitation
Lead Sponsor:
Ruhr University of Bochum
Conditions:
Heart Arrest
Ventricular Fibrillation
Eligibility:
All Genders
18+ years
Brief Summary
Time-limited adaptive responses of thyroid function are common in the critically ill. About 70% of all patients treated on intensive care units develop a so-called non-thyroidal illness syndrome (NTIS...
Detailed Description
Transient allostatic responses of thyroid function are common in the critically ill. About 70% of all patients treated on intensive care units develop a so-called non-thyroidal illness syndrome (NTIS)...
Eligibility Criteria
Inclusion
- Admission after cardiopulmonary resuscitation
- Minimum age of 18 years
- Results of TSH and peripheral thyroid hormone concentrations already available or possibility to reorder these investigations in a post-hoc manner if consent has been obtained (i. e. time interval after venipuncture within the storage period of the central laboratory)
- Inclusion after own consent of the patient after reawakening, via custodian or independent consultant.
Exclusion
- Missing data on thyroid homeostasis in the first blood specimen (obtained before 3 hours after admission)
- Traumatic brain injury
- Persistent hints for thyroid dysfunction, not explained by non-thyroidal illness syndrome (NTIS) / euthyroid sick syndrome (ESS) / thyroid allostasis in critical illness, tumors, uremia and starvation (TACITUS) in consecutive investigations over several days after resuscitation
- Functionally relevant thyroid or pituitary disorder, as documented in international classification of diseases (ICD) codes.
- Exposure to radiocontrast agents less than 3 months ago
- Therapy with amiodarone (currently or during the previous 3 years)
- Pregnancy
- Known thyroid disease
- Consent not obtained within the routine storage period of the central laboratory
- Post-hoc-exclusion if evidence for true dysfunction the the pituitary or the thyroid became available during the study period.
Key Trial Info
Start Date :
May 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04392258
Start Date
May 1 2021
End Date
December 31 2022
Last Update
August 19 2021
Active Locations (1)
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1
Medizinische Klinik I, Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum
Bochum, North Rhine-Westphalia, Germany, D-44789