Status:
UNKNOWN
Post-treatment Ultrasensitive Positron Emission Tomography in Nasopharyngeal Carcinoma Patients
Lead Sponsor:
Sun Yat-sen University
Conditions:
Nasopharyngeal Carcinoma
Eligibility:
All Genders
18-70 years
Brief Summary
NPC Patients receiving IMRT treatment will receive a dedicated FDG PET/CT and high-sensitivity PET/CT protocol simultaneously in the follow-up of Locally Advanced Nasopharyngeal Carcinoma. Hence we es...
Detailed Description
Newly-diagnosed patients with stage III or IV non-metastatic Nasopharyngeal Carcinoma (AJCC 8th) will be recruited. All subjects receiving chemoradiotherapy will undergo a baseline integrated \[18F\]f...
Eligibility Criteria
Inclusion
- Patients must be informed of the investigational nature of this study and given written informed consent.
- Aged between 18-70, male/female.
- Staged III or IV (AJCC 8th) NPC patients with histologically confirmed non-keratinizing nasopharyngeal carcinoma (including differentiated type and undifferentiated type, WHO II and III).
- Received induction chemotherapy and/or concurrent chemoradiotherapy. ECOG scale 0-1.
- Fertile women should practice contraception during the study period.
- HGB ≥90g/L ,WBC ≥4\*109/L , PLT ≥100\*109/L,
- With normal liver function test (ALT and AST ≤2.5\*ULN, TBil ≤2.0\*ULN)
- With normal renal function test (serum creatinine ≤1.5\*ULN)
Exclusion
- Women in pregnancy or lactation
- Prior malignancy except adequately treated basal cell, squamous cell skin cancer, or cervical cancer in situ.
- Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose \>1.5×ULN), and emotional disturbance.
- Already involved in other clinical trial.
- Mental disorder, civil disability, limited capacity for civil conduct.
Key Trial Info
Start Date :
May 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 20 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04394091
Start Date
May 20 2020
End Date
December 20 2020
Last Update
May 19 2020
Active Locations (1)
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1
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060