Status:
ACTIVE_NOT_RECRUITING
Ultra High Resolution CT to Assess Role of Intramyocardial Fat and Delayed Enhancement in Ventricular Arrhythmogenesis
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Canon Medical Systems, USA
Conditions:
Ventricular Arrhythmias
Eligibility:
All Genders
18-85 years
Brief Summary
This research is being done to determine how well cardiac computed tomography (CT) scanning measures of fat within the heart can predict abnormal heart rhythms and how well cardiac CT can measure scar...
Detailed Description
The investigators aim to investigate the role of intramyocardial fat on ventricular arrhythmogenesis. Intramyocardial fat deposition has been frequently observed in patients with ischemic heart diseas...
Eligibility Criteria
Inclusion
- Patients aged 18 or older with history of ischemic cardiomyopathy enrolled in the current Reynolds study or PROSe-ICD study will be asked to participate
- Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CT
- Ability to understand and willingness to sign the Informed Consent Form
Exclusion
- Known allergy to iodinated contrast media
- Patients with glomerular filtration rate (GFR) ≤ 30 mL/min will not be enrolled in the study due to the use of intravenous iodinated contrast agents
- Atrial fibrillation or uncontrolled tachyarrhythmia
- Evidence of severe symptomatic heart failure (NYHA Class III or IV)
Key Trial Info
Start Date :
March 4 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT04394637
Start Date
March 4 2021
End Date
May 1 2027
Last Update
May 23 2025
Active Locations (1)
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1
Johns Hopkins Medical Institute
Baltimore, Maryland, United States, 21287