Status:

COMPLETED

COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss

Lead Sponsor:

Hôpital de Verdun

Conditions:

Coronavirus Infection

COVID

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

Prone positioning is an established intervention in mechanically ventilated acute respiratory distress syndrome (ARDS) patients, with demonstrated reductions in mortality. Preliminary data suggest th...

Eligibility Criteria

Inclusion

  • COVID-19, either confirmed by SARS-CoV-2 assay, or clinically suspected, with results of the assay pending;
  • Lung infiltrates documented on chest X-ray or chest CT-scan;
  • Significant respiratory distress that requires treatment with HFNO.

Exclusion

  • Unable to consent;
  • Unable to prone;
  • Indication for immediate endotracheal intubation and mechanical ventilation;
  • Contraindication to prone positioning (severe obesity, abdominal wound, pregnancy, unstable pelvic/spinal lesions, vomiting, etc.);
  • Comfort care or imminent expectation of death.

Key Trial Info

Start Date :

May 15 2020

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

March 15 2021

Estimated Enrollment :

13 Patients enrolled

Trial Details

Trial ID

NCT04395144

Start Date

May 15 2020

End Date

March 15 2021

Last Update

March 23 2021

Active Locations (5)

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Page 1 of 2 (5 locations)

1

Hôtel-Dieu de Gaspé

Gaspé, Quebec, Canada, G4X 2W2

2

Hôpital de la Cité-de-la-Santé

Laval, Quebec, Canada, H7M 3L9

3

Montreal General Hospital, McGill University Healthcare Center

Montreal, Quebec, Canada, H3G 1A4

4

Royal Victoria Hospital, McGill University Healthcare Center

Montreal, Quebec, Canada, H4A 3J1