Status:
COMPLETED
The Effect of a Single Dose of Lamotrigine on Brain Function in Healthy Volunteers
Lead Sponsor:
University of Oxford
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study will test whether a single dose of Lamotrigine (300mg) exerts significant effects on emotional processing, cognitive ability and neural activity in healthy volunteers compared to placebo.
Detailed Description
Glutamate has been implicated in the aetiology of mood disorders and there is current interest in developing novel agents targeting this system. However, the role of glutamate in human emotional funct...
Eligibility Criteria
Inclusion
- Male or female
- Aged 18-40 years
- Willing and able to give informed consent for participation in the study
- Sufficiently fluent English to understand and complete the task
Exclusion
- Current usage of psychoactive medication
- Current usage of the contraceptive pill
- Any past or current Axis 1 DSM-IV psychiatric disorder
- Significant medical condition
- Current pregnancy or breastfeeding
- Current or past history of drug or alcohol dependency
- Participation in a psychological or medical study involving the use of medication within the last 3 months
- Previous participation in a study using the same, or similar, emotional processing tasks
- Smoker \> 5 cigarettes per day
- Typically drinks \> 6 caffeinated drinks per day
- Takes folic acid supplements
- History of recurrent allergies and rashes
- Contraindication to MRI (e.g. claustrophobia and metallic implants)
Key Trial Info
Start Date :
May 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2019
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04396938
Start Date
May 10 2017
End Date
August 30 2019
Last Update
May 21 2020
Active Locations (1)
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1
University of Oxford
Oxford, Oxfordshire, United Kingdom, OX3 7JX