Status:
UNKNOWN
Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3
Lead Sponsor:
National University of Malaysia
Collaborating Sponsors:
Radboud University Medical Center
Conditions:
Spinocerebellar Ataxia Type 3
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This study evaluates the effectiveness of oral trehalose in alleviating the neuropathological and motor behaviour deficits among patients with SCA3. A total of 40 participants with SCA3 will be recrui...
Detailed Description
Spinocerebellar ataxia 3 (SCA3) is a rare form of inherited neurodegenerative disease involving progressive degeneration of spinocerebellar tract. SCA3 is characterised by increasingly worsening cereb...
Eligibility Criteria
Inclusion
- Age between 18 and 85 years old.
- Genetically confirmed SCA 3 diagnosis.
- Presence of progressive cerebellar syndrome (i.e. symptomatic) and genetic confirmation of SCA 3 in one of the immediate family members with similar clinical syndrome.
- Able to read, speak, and understand English or Malay.
Exclusion
- Diagnosis of Diabetes Mellitus Type 1 or Type 2
- Presence of any concomitant neurological condition that might interfere with clinical measures used in this study.
- Presence of contraindication or hypersensitivity to trehalose.
- Use of stimulant / medication, caffeine, and tobacco within less than 24 hours washout period prior to assessment and / or scan.
- Presence of severe visual and / or auditory perceptual deficits.
- MRI contra-indications: claustrophobia, pregnancy, electronic implants (e.g. pacemaker) in the body, aneurysm clip, and current or past employment as machinists, welders or metal workers.
Key Trial Info
Start Date :
February 24 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2023
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04399265
Start Date
February 24 2020
End Date
June 30 2023
Last Update
August 16 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UKM Medical Centre
Cheras, Kuala Lumpur, Malaysia, 56000