Status:
UNKNOWN
Effect of Oxalate and Urate Metabolism on CKD Evolution
Lead Sponsor:
The Institute of Nephrology of the Academy of Medical Sciences of Ukraine
Conditions:
CKD
ESRD
Eligibility:
All Genders
18-85 years
Brief Summary
The current study primarily aimed to characterize the oxalate and uric acid metabolism in CKD patients and to analyze its association with renal survival prognosis. Secondarily, the study is planned t...
Detailed Description
The study protocol is approved by a local Ethics Committee and registered in Domestic Clinical Trial Registry (Identifier 0119U000002). Writing informed consent is obtained from all subjects participa...
Eligibility Criteria
Inclusion
- age \>18 years old,
- CKD stage 1-4,
- the patients did not take antibiotics and/or probiotics, lipid- and/or urate-lowering therapy for at least past 3 months or:
- dialysis treatment for at least 3 months,
- a stable clinical condition and adequately functioning arteriovenous fistula or peritoneal access,
- a target level of Kt/V (≥ 1.4 for the HD patients and ≥1.7 for the PD patients).
Exclusion
- hospitalization in the preceding 3 months,
- previous history or actual diagnosis of peritonitis, anemia, systemic and malignant diseases, acute inflammation processes, immunosuppressive treatment and active hepatitis.
Key Trial Info
Start Date :
January 10 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT04399915
Start Date
January 10 2019
End Date
December 1 2024
Last Update
May 22 2020
Active Locations (1)
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1
Natalia Stepanova
Kyiv, Ukraine, 04050