Status:
COMPLETED
A Study of Fluzoparib (SHR-3162) and Temozolomide With or Without SHR-1316 in Treating Patients With Replapsed Small Cell Lung Cancer
Lead Sponsor:
Jiangsu HengRui Medicine Co., Ltd.
Conditions:
Small Cell Lung Cancer
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
PHASE2
Brief Summary
This research study is a multicentre phase Ⅰb/Ⅱ Study to evaluate the efficacy and safety of the combination of Fluzoparib (SHR-3162) and temozolomide with or without SHR-1316 in small cell lung cance...
Eligibility Criteria
Inclusion
- Subjects who have recurrent small cell lung cancer confirmed by histology or cytology.
- Failed one prior line of platinum-based chemotherapy.
- Subjects must have measurable disease, at least one lesion, by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) per RECIST 1.1 criteria (within 28 days prior to administration of study treatment) ;
- Freshly acquired samples or archived specimens within 12 months before randomization must be provided.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
- Participant must have a life expectancy ≥ 12 weeks.
Exclusion
- Active or untreated central nervous system (CNS) metastases.
- Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures.
- History of autoimmune disease.
- Positive test result for human immunodeficiency virus (HIV).
- Active hepatitis B or hepatitis C.
- Severe infections.
- Subjects with a condition requiring systemic treatment with either corticosteroids (\>10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days of first administration of study treatment.
- Significant cardiovascular disease.
- History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or is not in the best interest of the subject to participate, in the opinion of the treating investigator.
Key Trial Info
Start Date :
June 11 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 15 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04400188
Start Date
June 11 2020
End Date
January 15 2022
Last Update
June 29 2025
Active Locations (1)
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1
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610015