Status:
RECRUITING
The IMmunotherapy Pleural 5-ALA PDT
Lead Sponsor:
University Hospital, Lille
Collaborating Sponsors:
INSERM U1189 ONCOTHAI
Conditions:
Mesotheliomas Pleural
Malignant Pleural Mesothelioma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Pilot study of the feasibility of an innovative multimodal treatment combining intrapleural photodynamic therapy with videothoracoscopy followed by adjuvant immunotherapy with anti-PD-1 Nivolumab anti...
Eligibility Criteria
Inclusion
- ECOG Performance status (PS) 0-1 (WHO)
- Unresectable Malignant Pleural Mesothelioma
- suffering from unresectable MPM (n=20), relapsing after one or 2 lines of treatment with platinum-based doublet of chemotherapy (including pemetrexed) \[Note: MPM patients having contra-indications for, or refusing chemotherapy may also be recruited\], and candidate for palliative pleural procedure (i.e. thoracoscopy for pleurodesis by talc or by insertion of indwelled pleural catheter, IPC)
- Documented progression after previous 1 or 2 lines of chemotherapy including Platinum/Pemetrexed chemotherapy\*
- Measurable disease according to modified RECIST 1.1. for MPM
- Malignant pleural lesion assessed to be accessible by local PDT treatment during thoracoscopy, as validated by expert MTB ("MESOCLIN", Lille, France)
- Histological diagnosis confirmed by national expert pathology panel ("MESOPATH" - Institut Léon Bérard, Lyon, France)
- Weight loss \<10%
- available tumor tissue (archival or fresh)
- obtention of an informed written consent before any specific procedure of the study
- Decision to treat the patient within this clinical trial taken during MPM dedicated multidisciplinary board (RCP MESOCLIN in France )
- Patient affiliated to and covered by social security for standard care
- Women of child-bearing potential must use a highly effective method of contraception for 28 days prior to the first dose of investigational product, and must agree to continue using such precautions for 5 months after the final dose of investigational product
- Women of child-bearing potential must have a negative pregnancy test within 24h before administration of investigational product
- First line patients may also be recruited if they declined or if they have contra-indications for chemotherapy.
Exclusion
- lack of informed written consent; or refusal to sign or to participate
- Pregnant, breastfeeding patients, and female patients of childbearing potential who are unwilling or unable to use a highly effective method of contraception as outlined in the protocol for the duration of the study and for at least 5 months after the last dose of nivolumab
- Male patients who are unwilling or unable to use contraception methods for the duration of the study and for at least 7 months after the last dose of nivolumab
- a previous treatment by anti-PD-1 or anti-PD-L1 antibodies for their cancer or any other cancer in the last 5 years
- hypersensitivity to Nivolumab (anti-PD-1 antibodies)
- contra-indications for 5-ALA or PDT
- contra-indications for thoracoscopy (VATS)
- any other comorbidity precluding the feasibility of the therapeutic protocol: uncontrolled cardiac failure, pulmonary hypertension, liver or kidney severe dysfunction (creatinin clearance \<60 ml/min), uncontrolled infection, or other disease according to the investigator
- other cancer treated within 5 years before inclusion except baso-cellular skin carcinoma or cervical / bladder in situ carcinoma
- inability to receive study information and to give informed consent
- patient unable to have a clinical follow-up due to psychological, familial, social or geographical reasons
- legal incapacity (people in jail), or under supervision (i.e. guardianship or curatorship)
- treatment with experimental drug within 30 days before the start of the study
Key Trial Info
Start Date :
May 9 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 9 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04400539
Start Date
May 9 2022
End Date
May 9 2026
Last Update
September 25 2025
Active Locations (1)
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1
Institut Coeur-Poumon, CHU
Lille, France, 59037