Status:
TERMINATED
Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19
Lead Sponsor:
Marvin McCreary, MD
Conditions:
COVID-19
Eligibility:
All Genders
45+ years
Phase:
PHASE2
Brief Summary
Resveratrol is a plant polyphenol (that is sold commercially as a supplement) that might help fight coronavirus as well as help protect the body from the effects of disease (COVID-19) caused by the in...
Detailed Description
This randomized placebo-controlled trial is for the outpatient treatment of (Coronavirus Disease 2019) COVID-19. The purpose of this trial is to evaluate the safety and explore the effectiveness of re...
Eligibility Criteria
Inclusion
- Outpatients who test positive for infection with SARS-CoV-2.
- Age ≥45 years
- Mild COVID-19 based on World Health Organization (WHO) Baseline Severity Categorization
- Symptom duration ≤ 10 days, or \<72 hours of new respiratory symptoms.
- Patient must have access to the internet or a smartphone to complete surveys.
- English-speaking patients
Exclusion
- Diagnosed or suspected cognitive impairment that would prevent the patient from cooperating with study procedures, as judged by the screening clinician
- Asymptomatic patients (e.g. patients who were screened without symptoms but tested positive)
- Known or suspected liver disease or Hepatitis C
- Known kidney disease with estimate Glomerular Filtration Rate (eGFR) \<60
- Patients on warfarin, Novel Oral Anticoagulants (NOACs), HIV Protease Inhibitors, immunosuppressants, hydroxychloroquine/chloroquine, and other medication with a narrow therapeutic window.
- Allergy to grapes or rice.
- Co-morbidities with a high likelihood of hospitalization within 30 days (e.g., current cancer treatment, severe Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF))
- Currently pregnant
- Hospitalization
Key Trial Info
Start Date :
September 13 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2021
Estimated Enrollment :
105 Patients enrolled
Trial Details
Trial ID
NCT04400890
Start Date
September 13 2020
End Date
March 1 2021
Last Update
February 24 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Mt Carmel HealthSystems
Columbus, Ohio, United States, 43213