Status:
COMPLETED
Effect of Glycopyrrolate on Vasopressors Requirement for Non-elective Caesarean Section Under Spinal Anaesthesia
Lead Sponsor:
Rajesh Deshar
Conditions:
Glycopyrrolate
Post-spinal Hypotension
Eligibility:
FEMALE
18-40 years
Phase:
PHASE4
Brief Summary
This is prospective randomised double blind study conducted in parturients planned for non-elective caesarean section under spinal anaesthesia. Glycopyrrolate group will receive 0.2 mg of Glycopyrrola...
Detailed Description
Intravenous glycopyrrolate has been investigated for its effect on haemodynamic changes after spinal anesthesia for caesarean delivery. Results from previous studies are conflicting as glycopyrrolate ...
Eligibility Criteria
Inclusion
- Age between 18-40 years
- All parturients at term (gestational weeks ≥ 37)
- ASA (American society of Anaesthesiologist) PS (Physical status) grade II
Exclusion
- Age \>40 year
- ASA PS Grade \>2
- Maternal bradycardia (baseline HR\< 60/min) or tachycardia (baseline HR\> 100/min)
- Pregnancy induced hypertension
- Gestational hypertension
- Known fetal abnormalities
- Intrauterine growth retardation (IUGR)
- Intrauterine fetal death (IUFD)
- Contraindications to spinal anaesthesia
- Contraindications to glycopyrrolate
- Multiple pregnancy
- BMI: \> 30 kg/m2
- Height: \<150cm
Key Trial Info
Start Date :
June 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2021
Estimated Enrollment :
258 Patients enrolled
Trial Details
Trial ID
NCT04401345
Start Date
June 1 2020
End Date
January 31 2021
Last Update
February 21 2021
Active Locations (1)
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1
B.P.Koirala Institute of Health Sciences
Dharān, Koshi, Nepal, 56700