Status:
COMPLETED
Different Susceptibility to SARS CoV-2 Infection Among Health Care Workers Highly Exposed to COVID-19.
Lead Sponsor:
Asociacion para el Estudio de las Enfermedades Infecciosas
Conditions:
Health Care Worker Patient Transmission
Receptor Site Alteration
Eligibility:
All Genders
18-65 years
Brief Summary
The primary objective of this study is to establish differences in susceptibility to SARS CoV-2 infection among health care workers (HCW) highly exposed to patients with COVID-19 diagnosis. To ascerta...
Detailed Description
Only 24% of health care workers (HCW) had developed inmunological response to SARS CoV-2 infection in one centre attending thousands of COVID-19 patients, and with shorteness of personal protective eq...
Eligibility Criteria
Inclusion
- Inclusion criteria
- HCW older than 18 years
- Highly exposed to COVID-19 according to the definition
- Negative (cases) or positive (controls) serology against SARS-CoV-2 infection Exclusion criteria
- Presence of any disease / treatment which could alter the susceptibility (corticoid therapy, chemotherapy, monoclonal antibodies)
- Pregnancy
- High exposure definition: direct and continued care of COVID-19 diagnosed patients for 2 weeks or more, without aerosol- generating procedures, with inappropriate personal protective equipment (PPE), or unprotected exposure to patients with COVID-19 during aerosol-generating procedures.
- The definition of appropriate PPE was based on previous recommendations. The absence of any part of the PPE constituted an unprotected exposure. We defined the following as aerosol-generating procedures: airway suction, application of a high-flow O2 instrument, bronchoscopy, endotracheal intubation, tracheostomy, nebulizer treatment, sputum induction, positive pressure ventilation, manual ventilation and cardiopulmonary resuscitation.
Exclusion
Key Trial Info
Start Date :
August 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 30 2021
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04402827
Start Date
August 1 2020
End Date
September 30 2021
Last Update
October 26 2021
Active Locations (1)
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1
Hospital Ramon y Cajal
Madrid, Spain, 28034