Status:
ACTIVE_NOT_RECRUITING
Left Atrial Posterior Wall Additional Isolation for Persistent Atrial Fibrillation Trial
Lead Sponsor:
Institute for Clinical Effectiveness, Japan
Conditions:
Persistent Atrial Fibrillation
Catheter Ablation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose for this study is to determine whether left posterior wall isolation (PWI) in addition to pulmonary vein isolation (PVI) is effective as ablation strategy for persistent atrial fibrillatio...
Detailed Description
PVI is cornerstone of AF ablation. However, clinical outcome of only PVI in patients with persistent AF is insufficient due to AF substrate extending to left atrium. Strategy of catheter ablation for ...
Eligibility Criteria
Inclusion
- Patients scheduled for first catheter ablation of persistent atrial fibrillation
- Patients without conversion to sinus rhythm within 30 days after antiarrhythmic drug administration
- Patients with persisting duration of atrial fibrillation less than 3 years
- Patients with left atrial diameter less than 50mm
- Patients who can be followed up for 18 months
- Patients with written informed consent
Exclusion
- Patients who can not be received adequate anticoagulation therapy
- Patients with history of myocardial infarction within 6 months
- Patients with history of open heart surgery
- Patients scheduled for open heart surgery
- Patients with severe valvular heart disease
- Patients during pregnancy
- Patients with expected life expectancy less than 1 year due to malignancy or non-cardiovascular disease
- Patients considered unsuitable for study by the attending physician
Key Trial Info
Start Date :
June 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2026
Estimated Enrollment :
276 Patients enrolled
Trial Details
Trial ID
NCT04405258
Start Date
June 8 2020
End Date
June 30 2026
Last Update
June 14 2024
Active Locations (1)
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1
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, Japan, 760-8557