Status:
COMPLETED
Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
Lead Sponsor:
Stanford University
Collaborating Sponsors:
University of California, San Diego
Conditions:
Olfactory Disorder
Olfaction Disorders
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the treatment of olfactory dysfunction. PrP can be isolated from a patient's own blood and has been found in p...
Detailed Description
Olfactory dysfunction constitutes a common impairment in the general population, affecting nearly 20 million in the USA and severely impairing quality of life. Unfortunately, this problem is often per...
Eligibility Criteria
Inclusion
- Patients \>= 18 years of age
- Patients who have olfactory loss (based off of UPSIT score \<= 33 out of 40)
- Patients who also have an age-adjusted TDI Sniffin' Sticks score that demonstrates hyposmia (TDI\>16 and \<30)
- Etiology of olfactory loss is due to URI or idiopathic
- At least 6 months of olfactory loss but less than 12 months
- Patients can have been previously treated with oral and topical steroids but this is not a requirement
- Patients will receive concurrent olfactory training - the practice of smelling strong odors (standard of care)
- Be able to read and understand English
- Agree to participate in the study
- Be able and willing to provide Informed Consent
Exclusion
- Patients \< 18 years of age
- Pregnant females
- Patient who have any structural abnormalities on nasal endoscopy or radiographic imaging
- Olfactory loss due to trauma, chronic sinusitis / inflammation / polyps, neoplasms, or neurodegenerative diseases
- Patients who have had olfactory loss \> 12 months
- Patients with bleeding disorders or on blood thinners such as coumadin and plavix
Key Trial Info
Start Date :
June 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 11 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04406584
Start Date
June 22 2021
End Date
August 11 2022
Last Update
March 13 2023
Active Locations (2)
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1
University of California - San Diego
San Diego, California, United States, 92093
2
Stanford University
Stanford, California, United States, 94305